RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Ezh2
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis
Year
2016
Function
EZH2 was upregulated in the lungs of patients with IPF and in mice with bleomycin-induced lung fibrosis. EZH2 induces the differentiation of fibroblasts to myofibroblasts by enhancing Smad2/3 nuclear translocation.